Probio4 brings together four distinct strains, each registered and genetically identified: Lactobacillus rhamnosus LGG, the most researched probiotic bacterium in the world, Bifidobacterium lactis BB-12, Lactobacillus acidophilus LA-5, and Lactobacillus reuteri LRC. More than 600 clinical studies focus specifically on these four strains, offering an exceptional level of scientific evidence in the probiotics field. Their precise identification allows for reliable reproducibility of results, and the scientifically validated synergy between LGG and BB-12 produces effects on gut-flora restoration that are considerably greater than any single strain alone.

Probio4 acts across the whole of gut-flora balance. The four strains cover complementary functions: supporting digestion, maintaining microbiome balance, reinforcing natural defences, and improving transit. This complex is particularly relevant after a course of antibiotics, during seasonal changes, or in periods of stress — all situations that can disrupt gut flora. Clinical data confirms that combining several complementary, non-competing strains broadens the benefits obtained, spanning digestion, immune support and even skin health, an area traditionally linked to gut-microbiome balance.

Probio4 uses vegetable DRcaps capsules, known for their resistance to stomach acid — this gastro-resistant technology ensures the probiotics survive the highly acidic stomach environment to deliver their full potential in the small intestine and colon, where they act. The patented CSP Active-vial bottle, opaque and protective, limits the impact of humidity and light on the sensitive strains, maintaining live bacteria counts for two years after manufacture at room temperature, with no need for refrigeration.

Recommended dose: 1 to 2 capsules a day, ideally on an empty stomach or with a light meal — morning intake is generally preferred to optimise gut colonisation, with adequate hydration. A course of at least 30 days is recommended to see initial results on digestive comfort and gut-flora balance; the 28-capsule pack covers one month at 1 capsule a day. Mild issues such as bloating may occur in the first few days — adjust frequency if needed. Avoid taking at the same time as antibiotics: leave a gap of at least two hours.

This food supplement is not a substitute for a varied, balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. Keep out of reach of young children. Immunocompromised people or those with a central venous catheter should consult a healthcare professional before taking probiotics. Pregnant or breastfeeding women can generally use this product, but medical advice is recommended if in doubt. If digestive discomfort persists beyond the first week, reduce the dose or pause temporarily. Fructose-intolerant individuals should note the inulin content.

What makes Probio4 different from a standard probiotic?

Probio4 uses only authenticated strains backed by more than 600 clinical studies, with a DRcaps coating that protects the bacteria all the way to the gut — unlike many market blends with vaguer, less stable compositions.

Does Probio4 need to be refrigerated?

No — the patented CSP Active-vial bottle keeps the strains stable for two years at room temperature. Just avoid direct heat, humidity or light.

Can Probio4 be taken during or after a course of antibiotics?

Yes, probiotics are commonly used alongside antibiotics to support gut flora. Leave at least a two-hour gap between Probio4 and the antibiotic dose, and the probiotic course can continue after the antibiotic treatment ends to help restore microbiome balance.

Herba Barona is an independent specialist supplement shop in the heart of Paris — established in 2006. What you order is genuinely on our shelves: we ship from our own stock, with no dropshipping and no long waits.

Visit us at 10 rue Théophile Roussel, Paris 12 — or use Click & Collect and pick up your order in-store. We also deliver across France and Europe. Friendly, expert advice in English from our team.

Where is the shop?

Herba Barona is at 10 rue Théophile Roussel, 75012 Paris — a two-minute walk from Ledru-Rollin (line 8), close to Bastille. Open Tuesday to Saturday, 9:30 am–6:30 pm.

Can I order online or collect in store?

Yes. We ship across France and Europe under the same conditions as our French store, or choose Click & Collect to pick up your order for free at our Paris shop.