Bisglycinate is a third-generation magnesium form: each magnesium atom is bound to two glycine molecules, letting it use the amino-acid absorption pathway rather than competing with other minerals, with no laxative water-draw effect. Compared to older forms — oxide (1st gen, ~4% bioavailability, marked laxative effect) and citrate (2nd gen, ~16% bioavailability, possible digestive discomfort) — bisglycinate (20–25% bioavailability) combines high absorption with excellent tolerance, making it well suited to prolonged daily use, with glycine adding a gentle calming effect.

Magnesium contributes to normal nervous system function and normal psychological function (EFSA); insufficient intake can show up as increased nervousness, trouble falling asleep or heightened stress sensitivity. Taurine supports cellular magnesium retention and nervous regulation, while active P5P vitamin B6 improves the mineral’s cellular absorption. Magnesium also contributes to normal muscle function — insufficient intake can show as muscle tension, night cramps or eyelid twitching, common among active people and athletes.

Magnesium contributes to reduced tiredness and fatigue and to normal energy metabolism, involved in over 300 enzymatic reactions. Take 2–3 capsules a day with a large glass of water, ideally in the evening with dinner, as bisglycinate suits evening use thanks to glycine’s relaxing effect (or split 1 morning, 2 evening). At 3 capsules/day (300mg), a bottle lasts 40 days; at 2/day (200mg), 60 days. First effects are usually felt after 2–4 weeks; a course of at least 3 months is recommended.

It can be taken continuously by people with normal kidney function and combines well with vitamin D and omega-3. Avoid taking at the same time as calcium or iron — space by 2 hours.

Do not exceed 3 capsules a day. Not recommended for pregnant or breastfeeding women without medical advice. People with kidney impairment should consult their doctor, as the kidneys clear excess magnesium. If on antibiotics (tetracyclines, quinolones), allow a 2-hour gap. This food supplement is not a substitute for a varied and balanced diet and a healthy lifestyle. Keep out of young children’s reach.

Does bisglycinate cause a laxative effect?

No — unlike oxide or chloride forms, bisglycinate doesn’t draw water into the gut, making it the best-tolerated form for sensitive users and long courses.

How long does a bottle last?

40 days at 3 capsules/day, 60 days at 2 capsules/day — the lower dose suits maintenance, the higher dose periods of increased need.

Bisglycinate or citrate — which is better?

Citrate offers good bioavailability but can cause digestive discomfort. Bisglycinate offers equivalent or higher bioavailability with markedly better tolerance and a complementary relaxing effect from glycine.

Herba Barona is an independent specialist supplement shop in the heart of Paris — established in 2006. What you order is genuinely on our shelves: we ship from our own stock, with no dropshipping and no long waits.

Visit us at 10 rue Théophile Roussel, Paris 12 — or use Click & Collect and pick up your order in-store. We also deliver across France and Europe. Friendly, expert advice in English from our team.

Where is the shop?

Herba Barona is at 10 rue Théophile Roussel, 75012 Paris — a two-minute walk from Ledru-Rollin (line 8), close to Bastille. Open Tuesday to Saturday, 9:30 am–6:30 pm.

Can I order online or collect in store?

Yes. We ship across France and Europe under the same conditions as our French store, or choose Click & Collect to pick up your order for free at our Paris shop.