Flexine isn’t built around one ingredient but a multi-target formula acting at every level of the joint. Glucosamine (500 mg/capsule): an amino-sugar naturally present in cartilage, the precursor of glycosaminoglycans (GAGs), the molecules that form the cartilage matrix and give it compression resistance — the GAIT clinical study (2006) showed improved joint comfort after 8–12 weeks of supplementation at 1,500 mg/day. Marine chondroitin (400 mg/capsule): a proteoglycan naturally found in cartilage, complementary to glucosamine, which holds water in cartilage giving it its shock-absorbing property; the marine (fish) source offers better bioavailability than bovine chondroitin. MSM Opti-MSM (120 mg/capsule): a bioavailable form of organic sulfur, a structural component of collagen and keratin — Opti-MSM (Cardinal Nutrition, USA) is the world reference for distillation-purified MSM. Bamboo silicon (15 mg/capsule, 40% silicon): silicon is an essential trace element for collagen and elastin synthesis, and bamboo extract (Bambusa arundinacea) is the most concentrated plant source of bioavailable silicon. Manganese bisglycinate (0.75 mg/capsule): a cofactor for cartilage proteoglycan synthesis, in its best-absorbed chelated form.

The glucosamine-chondroitin combination is the most studied pairing in joint nutrition. The GAIT study (Glucosamine/Chondroitin Arthritis Intervention Trial, 2006), run by the US NIH on 1,583 patients, showed this combination was significantly more effective than either active alone for moderate to severe joint discomfort. Glucosamine supplies the building blocks of cartilage (GAG precursor), while chondroitin retains water in the cartilage matrix and inhibits the enzymes that break it down (metalloproteases) — glucosamine builds, chondroitin protects. Flexine’s dosage (1,000 mg glucosamine + 800 mg chondroitin per 2 capsules/day) matches the dosages used in clinical studies — a high dose, not a maintenance dose.

Joint comfort takes time — studies show initial effects after 4–8 weeks and optimal results after 3 months. That’s why the large 200-capsule format is recommended: it covers 100 days at 2 capsules/day, more than 3 months of continuous supplementation, is more economical than the 60-capsule format (lower price per capsule), and avoids running out mid-course. A 60-capsule format is also available to try the product first (30-day course).

Dose: 1 capsule in the morning + 1 in the evening, with meals and a large glass of water; splitting the dose provides continuous support over 24 hours. Minimum duration: 2 to 3 months, as joint actives work progressively on cartilage nutrition and protection. Pairs well with collagen (the structural cartilage protein — glucosamine + chondroitin plus collagen covers both pillars of joint nutrition), Boswellia serrata, curcumin, and omega-3 EPA.

Contains crustaceans (glucosamine source) and fish (chondroitin source): not recommended for people with these allergies. Not suitable for vegetarians or vegans (a plant-based glucosamine-chondroitin alternative is available). Not recommended for people with diabetes (glucosamine may affect blood sugar). Not recommended under anticoagulant treatment without medical advice. Not recommended for pregnant women or children under 12.

How long before I notice an effect?

Initial effects on joint comfort appear after 4–8 weeks; optimal results need 3 months of continuous use — exactly what the 200-capsule format covers.

Is Flexine suitable for vegetarians?

No — it contains glucosamine from crustaceans and chondroitin from fish. A plant-based glucosamine-chondroitin alternative is available for vegetarians and vegans.

Can Flexine be combined with collagen?

Yes — collagen is the structural protein of cartilage, while glucosamine and chondroitin support its building blocks. Together they cover both pillars of joint nutrition.

Herba Barona is an independent specialist supplement shop in the heart of Paris — established in 2006. What you order is genuinely on our shelves: we ship from our own stock, with no dropshipping and no long waits.

Visit us at 10 rue Théophile Roussel, Paris 12 — or use Click & Collect and pick up your order in-store. We also deliver across France and Europe. Friendly, expert advice in English from our team.

Where is the shop?

Herba Barona is at 10 rue Théophile Roussel, 75012 Paris — a two-minute walk from Ledru-Rollin (line 8), close to Bastille. Open Tuesday to Saturday, 9:30 am–6:30 pm.

Can I order online or collect in store?

Yes. We ship across France and Europe under the same conditions as our French store, or choose Click & Collect to pick up your order for free at our Paris shop.