Unlike hydrolysed collagen, which is broken into small peptides and loses its original structure, UC-II retains the intact triple-helix structure of native collagen. This structure is recognised by Peyer’s patches — lymphoid tissue in the small intestine central to immune regulation — triggering a tolerance process that modulates the immune response toward joint collagen. This explains why UC-II works at such a low dose (40 mg/day versus several grams for hydrolysed collagen) and why it is considered a functional ingredient rather than a simple nutritional supplement.

Type I collagen is the most abundant, forming the framework of bone, skin, tendons and ligaments; type III is found mainly in blood vessels, internal organs and skin. Type II collagen, by contrast, is specific to joint cartilage, making up around 90–95% of hyaline cartilage — which is why it is particularly relevant for joint comfort, distinct from the hydrolysed type I/III collagens more suited to skin, hair and nails.

Take 1 capsule a day, ideally on an empty stomach or with a light meal. First effects on joint comfort may be felt after several weeks of regular use — consistency matters more than occasional use.

Not a substitute for a varied, balanced diet. Do not exceed the recommended daily dose. Not recommended for people allergic to chicken or poultry products. Store in a cool, dry place away from direct light.

People experiencing joint discomfort linked to age, physical activity or a sedentary lifestyle, athletes in high-impact or joint-intensive disciplines, and people over 40 who notice morning stiffness. UC-II can be combined with other joint-support supplements (glucosamine, chondroitin, hyaluronic acid, omega-3s). Note: it contains chicken, so it is not suitable for a strict vegan diet, though the capsule shell itself is vegetable-based (HPMC).

Can UC-II replace standard hydrolysed collagen?

They work differently and are complementary — UC-II acts via low-dose oral tolerance, while hydrolysed collagen supplies amino acids for collagen synthesis. You can take both without any compatibility issue.

How long before I notice effects from UC-II?

Clinical studies show significant results after 60 to 90 days of continuous daily use, so a course of at least three months is recommended.

Herba Barona is an independent specialist supplement shop in the heart of Paris — established in 2006. What you order is genuinely on our shelves: we ship from our own stock, with no dropshipping and no long waits.

Visit us at 10 rue Théophile Roussel, Paris 12 — or use Click & Collect and pick up your order in-store. We also deliver across France and Europe. Friendly, expert advice in English from our team.

Where is the shop?

Herba Barona is at 10 rue Théophile Roussel, 75012 Paris — a two-minute walk from Ledru-Rollin (line 8), close to Bastille. Open Tuesday to Saturday, 9:30 am–6:30 pm.

Can I order online or collect in store?

Yes. We ship across France and Europe under the same conditions as our French store, or choose Click & Collect to pick up your order for free at our Paris shop.