Buy NAD+: cellular energy and longevity support
NAD+ by SIHO, in 60 capsules, is a next-generation complex combining nicotinamide riboside (NR), TMG and vitamins B2 and B3 to support cellular NAD+ production — a molecule at the centre of longevity research. Available at our Paris shop, with Click & Collect and delivery across France and Europe.
NAD+: a key molecule in cellular ageing
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme in every living cell, essential to the mitochondrial respiratory chain for energy production, to PARP enzymes for DNA repair, and to sirtuins — enzymes nicknamed “longevity genes” that regulate metabolism, inflammation and cellular stress resistance. NAD+ levels decline by roughly 50% between ages 40 and 60, a decline now considered one of the central mechanisms of ageing.
Why nicotinamide riboside
NR, discovered in 2004 by Prof. Charles Brenner, is the most direct NAD+ precursor, requiring only 2 enzymatic steps versus 3–5 for niacin, and unlike high-dose niacin does not cause flushing. Clinical trials in humans have shown significant increases in blood NAD+ following NR supplementation, with doses of 300–1,000 mg/day well tolerated.
The SIHO formula: four actives
Rather than NR alone, SIHO combines NR (main NAD+ precursor via the NRK pathway), TMG (a methyl donor that protects the body’s methylation pool, consumed when NR is metabolised into NAD+), vitamin B2 (a cofactor for FAD-dependent enzymes working alongside NAD+), and vitamin B3 (a complementary NAD+ precursor via the separate Preiss-Handler pathway) — feeding NAD+ through two distinct metabolic routes while protecting methylation.
How to use & precautions
Take 2 capsules a day in the morning with a glass of water. 60 capsules gives a 1-month course; a 3-month course is recommended for lasting effects. First effects on energy are typically felt after 2–4 weeks of regular use.
For adults. Not recommended for pregnant or breastfeeding women. Do not exceed the recommended dose.
Frequently asked questions
NAD+, NR or NMN: what’s the difference?
NAD+ is the final molecule cells need. NR and NMN are both NAD+ precursors — NR is the most clinically studied in humans, and it’s what this SIHO product contains.
From what age should I take NAD+?
NAD+ levels start declining from age 30–40, so supplementation is particularly relevant from 40 onward. Before that, good lifestyle habits (exercise, intermittent fasting) may be enough to maintain adequate levels.
Why buy from Herba Barona?
Herba Barona is an independent specialist supplement shop in the heart of Paris — established in 2006. What you order is genuinely on our shelves: we ship from our own stock, with no dropshipping and no long waits.
Visit us at 10 rue Théophile Roussel, Paris 12 — or use Click & Collect and pick up your order in-store. We also deliver across France and Europe. Friendly, expert advice in English from our team.
Delivery & collection
Where is the shop?
Herba Barona is at 10 rue Théophile Roussel, 75012 Paris — a two-minute walk from Ledru-Rollin (line 8), close to Bastille. Open Tuesday to Saturday, 9:30 am–6:30 pm.
Can I order online or collect in store?
Yes. We ship across France and Europe under the same conditions as our French store, or choose Click & Collect to pick up your order for free at our Paris shop.
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Food supplement. Does not replace a varied, balanced diet or a healthy lifestyle. Do not exceed the recommended daily dose. Keep out of reach of children.
