Standard synthetic folic acid must be converted into its active form (5-MTHF) by the liver before it can be used. However, a significant part of the population carries genetic variations (MTHFR polymorphism) that reduce this conversion capacity. The Quatrefolic (5-MTHF) in this product is already in its active form — the body assimilates it directly, with no transformation needed.

This product is particularly suited to people looking to optimise their vitamin B9 intake, notably during family planning, or for those who struggle to metabolise standard folic acid.

Vitamin B9 (folate) plays a fundamental role in DNA synthesis, cell division and red blood cell production. It also contributes to amino acid metabolism and to the reduction of homocysteine levels in the blood, a marker linked to cardiovascular health.

Folate needs increase notably during pregnancy (contributing to the neurological development of the foetus), with a diet low in green vegetables, or when taking certain medicines that can interfere with its absorption.

Doctor’s Best is an American brand founded in 1990 by physicians, recognised for the scientific rigour of its formulas. Every product is manufactured to GMP (Good Manufacturing Practices) standards and tested in independent laboratories to guarantee purity and dosage. Fully Active Folate 800 is non-GMO, vegan and gluten-free.

Recommended dose: 1 capsule per day with a meal. Store in a cool, dry place away from light.

Keep out of reach of children.

What’s the difference between folate and folic acid?

Folic acid is the synthetic form of vitamin B9, requiring enzymatic conversion in the liver. Active folate (5-MTHF Quatrefolic) is the directly bioavailable form, with no conversion step — particularly recommended for people with an MTHFR polymorphism.

Is this product suitable for vegans?

Yes, Fully Active Folate 800 by Doctor’s Best is entirely vegan: vegetable capsules, non-animal-derived ingredients, non-GMO and gluten-free.

Herba Barona is an independent specialist supplement shop in the heart of Paris — established in 2006. What you order is genuinely on our shelves: we ship from our own stock, with no dropshipping and no long waits.

Visit us at 10 rue Théophile Roussel, Paris 12 — or use Click & Collect and pick up your order in-store. We also deliver across France and Europe. Friendly, expert advice in English from our team.

Where is the shop?

Herba Barona is at 10 rue Théophile Roussel, 75012 Paris — a two-minute walk from Ledru-Rollin (line 8), close to Bastille. Open Tuesday to Saturday, 9:30 am–6:30 pm.

Can I order online or collect in store?

Yes. We ship across France and Europe under the same conditions as our French store, or choose Click & Collect to pick up your order for free at our Paris shop.