Postbiotics represent a significant step forward from traditional probiotics. Unlike live bacteria, which must survive gastric transit and then colonise the gut, postbiotics use inactivated micro-organisms whose benefits are documented by scientific research. This inactivation gives superior stability — no refrigeration needed, no risk of uncontrolled proliferation, and almost no digestive discomfort such as bloating or gas. Postbio 3 uses this technology, bringing together two complementary strains, each working through a distinct mechanism, for a targeted effect on gut immunity without disturbing the balance of the beneficial microbiota already in place — particularly suited to people who tolerate live probiotics poorly or want a more predictable, reassuring option for supporting their natural defences.

At the heart of Postbio 3, the Lactococcus lactis JCM5805 strain (Immuse) has been the subject of clinical studies showing its ability to activate plasmacytoid dendritic cells at Peyer’s patches, a key zone of gut immunity — this activation stimulates type I interferon production, contributing to normal immune system function, particularly useful over winter or during prolonged stress. The Lactobacillus reuteri DSM 17648 strain (Pylopass), developed by Novozymes in Denmark, works through an original physical mechanism: it has a specific affinity for certain unwanted bacteria present in the stomach and gut, binding to them and helping their natural elimination through transit, with no chemical antibacterial action involved. This dual action — immune and mechanical — makes Postbio 3 a distinctive formula on the French food supplement market.

The vitamin D3 in Postbio 3 comes exclusively from wild lichen, a 100% plant-based source suitable for vegan and vegetarian diets. Unlike classic vitamin D3 extracted from lanolin (sheep’s wool grease), this form respects the strictest dietary requirements while offering equivalent, or even superior, bioavailability thanks to micro-encapsulation technology, which protects the cholecalciferol molecule from oxidation and moisture-related degradation for lasting stability. Each daily dose covers 100% of the nutrient reference values for vitamin D, a nutrient essential for normal function of the immune system and the maintenance of normal bones — a logical pairing with the postbiotics, since vitamin D also plays a role in regulating the immune response in the gut.

Take 2 capsules a day with a large glass of water, ideally in the morning before breakfast — taking it on an empty stomach supports direct contact between the postbiotics and the gut lining. A 30-day course (one full 60-capsule bottle) is a good baseline for background immune support; over winter or periods of intense stress, the course can be extended to 2-3 consecutive months. Repeating the course at each change of season helps maintain balanced natural defences year-round.

Not recommended for pregnant or breastfeeding women without prior medical advice. If undergoing immunosuppressant treatment or living with an autoimmune condition, consult a healthcare professional before supplementing. Do not exceed the recommended daily dose. Store in a cool, dry place away from light. Keep out of reach of young children. Food supplements should not replace a varied, balanced diet and a healthy lifestyle.

What is the difference between a postbiotic and a probiotic?

A probiotic contains live bacteria that must colonise the gut to work. A postbiotic uses inactivated micro-organisms whose cellular components directly benefit the body. The main advantage of postbiotics is their superior stability, excellent digestive tolerance and the absence of risk linked to live bacteria proliferation. Postbio 3 combines two patented postbiotic strains for complementary immune support.

Can Postbio 3 be taken alongside a classic probiotic?

Yes — postbiotics are fully compatible with live probiotics, working through different mechanisms without competing. The combination can even be worthwhile for people wanting overall support for both microbiota and immunity, though it is always best to check with a healthcare professional to tailor dosages to your situation.

Why does Postbio 3 contain vitamin D3?

Vitamin D3 contributes to normal function of the immune system, making it a logical addition to the postbiotics, and vitamin D also plays a recognised role in regulating the gut’s immune response. Dynveo’s plant-based, micro-encapsulated form ensures optimal bioavailability and suits all diets, including vegan.

How long does it take to feel the effects of Postbio 3?

Early clinical studies on the Immuse and Pylopass strains observed measurable results after 4 to 8 weeks of regular use. Individual experience depends on many factors — initial microbiota state, diet, stress levels and sleep quality. A minimum 30-day course is recommended for the actives to fully support gut immunity.

Herba Barona is an independent specialist supplement shop in the heart of Paris — established in 2006. What you order is genuinely on our shelves: we ship from our own stock, with no dropshipping and no long waits.

Visit us at 10 rue Théophile Roussel, Paris 12 — or use Click & Collect and pick up your order in-store. We also deliver across France and Europe. Friendly, expert advice in English from our team.

Where is the shop?

Herba Barona is at 10 rue Théophile Roussel, 75012 Paris — a two-minute walk from Ledru-Rollin (line 8), close to Bastille. Open Tuesday to Saturday, 9:30 am–6:30 pm.

Can I order online or collect in store?

Yes. We ship across France and Europe under the same conditions as our French store, or choose Click & Collect to pick up your order for free at our Paris shop.