L-Citrulline is a non-protein amino acid first identified in watermelon in 1914 (its name comes from the Latin “citrullus”). The body produces it naturally in the gut and liver, but supplementation can be relevant in certain contexts. It is a key intermediate of the urea cycle — the pathway that clears toxic ammonia from protein metabolism — and an indirect precursor of nitric oxide (NO) via conversion to L-Arginine in the kidneys.

Oral citrulline raises plasma arginine levels more effectively and durably than direct arginine supplementation, because citrulline bypasses the liver and gut’s first-pass metabolism that heavily degrades ingested arginine before it reaches circulation. This supports nitric-oxide-driven vasodilation, improving blood flow to working muscles during exercise. Citrulline also helps clear ammonia and lactate produced during intense exercise, which may delay the onset of muscle fatigue, and contributes to the “pump” sensation popular among strength trainers. It’s typically taken 30–45 minutes pre-workout, at doses of 3–6g.

The powder format allows precise, personalised dosing based on body weight and activity level, and offers excellent value — the 200g pot provides 65–100 doses. It’s 100% pure L-Citrulline with no fillers, flavours or sweeteners, dissolves easily in water, and suits anyone who finds capsules difficult to swallow.

Mix 1 scoop (approx. 2–3g) in a large glass of water, 1–2 times a day. For sport, take 3–6g 30–45 minutes before training. Do not exceed 10g per day.

People on medical treatment, pregnant or breastfeeding women should consult a healthcare professional before use. This food supplement is not a substitute for a varied and balanced diet and a healthy lifestyle. Store in a cool, dry place away from light and reseal tightly after use.

L-Citrulline vs. citrulline malate — what’s the difference?

L-Citrulline is the pure amino acid; citrulline malate combines it with malic acid (usually 2:1), which can add an extra energy contribution via the Krebs cycle. Doctor’s Best’s powder is pure L-Citrulline, letting you dose the amino acid precisely.

When should I take citrulline for training?

Typically 30–45 minutes before training, at 3–6g, so plasma citrulline and arginine peak during exercise.

Is it suitable for vegetarians?

Yes — this L-Citrulline powder is 100% synthetic in origin, with no animal-derived ingredients, and suits vegetarians and vegans.

Herba Barona is an independent specialist supplement shop in the heart of Paris — established in 2006. What you order is genuinely on our shelves: we ship from our own stock, with no dropshipping and no long waits.

Visit us at 10 rue Théophile Roussel, Paris 12 — or use Click & Collect and pick up your order in-store. We also deliver across France and Europe. Friendly, expert advice in English from our team.

Where is the shop?

Herba Barona is at 10 rue Théophile Roussel, 75012 Paris — a two-minute walk from Ledru-Rollin (line 8), close to Bastille. Open Tuesday to Saturday, 9:30 am–6:30 pm.

Can I order online or collect in store?

Yes. We ship across France and Europe under the same conditions as our French store, or choose Click & Collect to pick up your order for free at our Paris shop.